I lost a very significant amount of weight whilst of Quetiapine. I was on a high dose and have been on many of the other new antipsychotics some of which I did have problems with appetite increase and weight gain. But I haven't had any issues with weight gain or increased appetite with quetiapine. I also have personally found it to be very helpful drug.
I do agree with others have said about making sure you are generally eating healthily. I hope it goes well for you
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