It has to be Thirty Whacks by The Dresden Dolls.
And it isn't really an uplifting song, but it's just comforting for me to know that I'm not the only one who feels this way. In this song Amanda Palmer just captured how I often feel perfectly - even the melody and the notes she hits, it all perfectly describes me, and it's often overwhelming to know someone I idolise so much understands the same feeling that I have.
[ame="http://www.youtube.com/watch?v=x4L_YjjlMOw"]The Dresden Dolls - Thirty Whacks - YouTube[/ame]
I guess it just makes me feel less alone :)