I read a blog a little while ago, it was called something like 'The Last Psychiatrist', I can't remember. Anyway, it explained how Quetiapine works. Basically, due to the way it works and the 'receptors' it works on, the drowsiness effect doesn't seem to increase after you hit 300mg. Around/after 300mg (up to 600) its antipsychotic effects work better.
P.S. Not sure how accurate or correct the blog was.
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