When sertraline was working for me I did find it made a difference, though at the higher end of the dosage scale. I was put on it in hospital and stayed on for about 4 years; was pretty effective for me and certainly didn't have the zombie-effect others have.
1 draw back (for me, and certainly for my boyf!) is that it killed my sex drive. Not that I have much anyway but it was certainly the final nail in that coffin!
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