In my experience, drinking alcohol has more of an effect when on medication (i.e. you get drunk/tipsy faster). Also, as said above as alcohol is a depressant, it can affect your moods. I have found that the next day my mood can be worse if have had a drink.
However, like most things with medicine and alcohol, everyone reacts differently. My advice would be that if you are going to drink, do not have too much and have at least one person around who can be your voice of reason.
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