Rapid metaboliser of medications shortening my half lives.
(I am on clomipramine, olanzapine and gabapentin)
I think my CYP450 enzymes are super efficient because I seem to metabolise drugs really fast.
I take 100mg clomipramine (probably due to be increased to 125mg) at night for OCD, anxiety and also to try and reduce my autistic meltdowns / challenging behaviour. I take it at 9pm every night. However at 6-7pm every evening I start flipping out. Last night I threw a glass against the wall, was screaming and ended up rolling on the floor bashing my fists against anything I could find (a typical meltdown). The night before that I was banging my head against the wall and screaming. It seems that my meds just wear off at that time, I even start feeling really wide awake and hypervigilant too at that time.
My question is, does anyone here have experience of split dosing of clomipramine? I have only got 50mg capsules so I can't try 25mg in the morning and 75mg at night. I know that clomipramine does give me quite a few side effects including postural hypotension (which has caused me to fall before) so I am quite concerned about that.
I take my olanzapine as split dosing but olanzapine only helps with my psychosis, not my challenging behaviour.